Publication List

2012

  • Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WT, Watt FM. (2012) Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials. [Epub ahead of print]
  • Collins CA, Jensen KB, Macrae EJ, Mansfield W, Watt FM. (2012) Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin. Dev Biol. [Epub ahead of print]
  • Chhatriwala MK, Cipolat S, Sevilla LM, Nachat R, Watt FM. (2012) Exons 5-15 of Kazrin Are Dispensable for Murine Epidermal Morphogenesis and Homeostasis. J Invest Dermatol. doi: 10.1038/jid.2012.110. [Epub ahead of print]
  • Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. (2012) Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol. 14: 401-408.
  • Arwert EN, Hoste E, Watt FM. (2012) Epithelial stem cells, wound healing and cancer. Nat Rev Cancer.12: 170-180.
  • Kretzschmar K, Watt FM. (2012) Lineage tracing. Cell. 148: 33-45.

2011

  • Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM. (2011) Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity. J Immunol
  • Driskell RR, Juneja VR, Connelly JT, Kretzschmar K, Tan DW, Watt FM. (2011) Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo. J Invest Dermatol.. doi: 10.1038/jid.2011.428.
  • Blanco S, Kurowski A, Nichols J, Watt FM, Benitah SA, Frye M. (2011) The RNA-Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate. PLoS Genet. 7:e1002403.
  • Watt FM.(2011) Stem cells: on the front line. J Cell Sci. 124 :3527-3528.
  • Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Ilieva EV, George J, Nicholson AG, Sage EK, Watt FM, Janes SM. (2011) β- catenin determines upper airway progenitor cell fate and pre-invasive squamous lung cancer progression by modulating epithelial-to-mesenchymal transition. Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Ilieva EV, George J, Nicholson AG, Sage EK, Watt FM, Janes SM. J Pathol. 2011 Nov 14. doi: 10.1002/path.3962.
  • Connelly JT, Mishra A, Gautrot JE, Watt FM. (2011)Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. PLoS One. 2011;6:e27259.
  • Burdick JA, Watt FM. High-throughput stem-cell niches. Nat Methods. 2011 Oct 28;8(11):915-916.
  • Collins CA, Kretzschmar K, Watt FM. Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development. 2011 Oct 26. [Epub ahead of print]
  • Arwert EN, Mentink RA, Driskell RR, Hoste E, Goldie SJ, Quist S, Watt FM. Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation. Oncogene. 2011 Jul 18.
  • Hunziker L, Benitah SA, Braun KM, Jensen K, McNulty K, Butler C, Potton E, Nye E, Boyd R, Laurent G, Glogauer M, Wright NA, Watt FM, Janes SM. Rac1 deletion causes thymic atrophy. PLoS One. 2011, 6:e19292.
  • Driskell RR, Clavel C, Rendl M, Watt FM. Hair follicle dermal papilla cells at a glance. J Cell Sci. 2011; 124:1179-1182.
  • Watt FM, Fujiwara H. Cell-extracellular matrix interactions in normal and diseased skin. Cold Spring Harb Perspect Biol. 2011. 3; pii: a005124.
  • Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM.The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011. 144: 577-589.
  • Quist SR, Miremadi A, Schreiner A, Sirokmany G, Watt FM. (2011) Role of Rac1 in Intercellular communication within the epidermis. Experimental Dermatology vol. 20 (pp.201-202)

    2010

  • Cho K, Vaught TG, Ji H, Gu D, Papasakelariou-Yared C, Horstmann N, Jennings JM, Lee M, Sevilla LM, Kloc M, Reynolds AB, Watt FM, Brennan RG, Kowalczyk AP, McCrea PD. Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. JCS. 2010. 123: 4128-4144.
  • Arwert EN, Lal R, Quist S, Rosewll I, van Rooijen N, Watt FM. Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. PNAS. 2010. 107: 19903-19908.
  • Ambler CA, Watt FM. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1. Development. 2010. 137: 3569-3579.
  • Connelly JT, Gautrot JE, Trappmann B, Tan D, Donati G, Huch W and Watt FM.Actin and serum responce factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology. 2010. 12: 711-718.
  • Jensen KB, Driskell RR and Watt FM. Assaying proliferation and diferentiation capacity of stem cells using disaggregated adult mouse epidermis. Nat Protoc. 2010. 5: 898-911.
  • Baker CM, Verstuyf, Jensen KB and Watt FM. Differential sensitivity of epidermal cell subpopulations to beta-catenin induced ectopic hair follicle formation. Dev Biol. 2010. In press.
  • Frye, M., Dragoni, I., Chin, S.F., Spiteri, I., Kurowski, A., Provenzano, E., Green, A.,          Ellis, I.O., Grimmer, D., Teschendorff, A., Zouboulis, C.C., Caldas, C.C. and Watt, F.M. Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer. Cancer Letters. 2010 12: 711-718.
  • Giangreco, A., Goldie, S.J., Failla, V., Saintigny, G. and Watt, F.M. Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP.
    J. Invest. Dermatol. 130: 604-608.
  • Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WT. Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials. 2010, 31: 5030-5041.
  • Watt FM and Jensen KB. Epidermal stem cell diversity and quiescence. EMBO Mol Med. 2009. 1: 260-267.
  • Berta MA, Baker CM, Cottle DL and Watt FM. Dose and content dependent effects of Myc on epidermal stem cell proliferation and differentiation. EMBO Mol Med. 2010. 2: 16-25.
  • Watt FM and Driskell RR. The therapeutic potential of stem cells. Philosophical transactions of the Royal Society, 2010. 365:155-163.

    2009

  • Nachat, R., Cipolat, S., Sevilla, L.M., Chhatriwala, M., Groot, K.R. and Watt, F.M. KazrinL is a novel desmosome-associated liprin that colocalises with acetylated microtubules. J Cell Sci. 2009 Nov 15;122(Pt 22):4035-41.
  • Giangreco, A., Jensen, K.B., Takai, Y., Miyoshi, J. and Watt, F.M. Necl2 regulates epidermal adhesion and wound repair. Development. 2009. 136, 3505-3514.
  • Driskell RR, Giangreco A, Jensen KB, Mulder KW and  Watt FM. Sox-2 positive dermal papilla cells specify hair follicle type in mammalian Epidermis. Development. 2009; 136(16): 2815-2823.
  • Giangreco A, Arwert, EN, Rosewell IR, Snyder J, Watt FM and Stripp BR. Stem Cell are dispensable for lung homeostatis but restore airways after injury. PNAS. 106: 9286-9291
  • Jensen KB, Collins CA, Nascimento E, Tan DW, Frye M, Itami S and Watt FM. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis. Cell Stem Cell . 2009. 4: 427-439.
  • Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, Narita M. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009 Mar 11
  • Ferreira M, Fujiwara H, Morita K and Watt FM. An Activating Beta-1 Integrin Mutation Increases the conversion of Bening to Malignant Skin Tumours. Cancer Res. 2009. 69: 1334-1342.
  • Sonnenberg A, Watt FM. Integrin special issue. J Cell Science. 2009 Jan 15;122(Pt 2):157.

    2008

  • Watt FM, Collins CA. Role of {beta}-catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer. Cold Spring Harb Symp Quant Biol. 2008 Nov 6.
  • Sevilla LM, Nachat R, Groot KR and Watt FM. Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation. Journal of Cell Science. 2008. 121(21): 3561-3569.
  • Collins CA and Watt FM. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Dev Biol. 2008 Sep 12.
  • Janes SM, Ofstad TA, Campbell DH, Eddaoudi A, Warnes G, Davies D and Watt FM. P13-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res. 2008 Sep 2.
  • Jensen KB, Jones J and Watt FM. A stem cell gene expression profile of human squamous cell carcinomas. Cancer letters. 2008. Jul 25
  • Sevilla LM, Rana AA, Watt FM and Smith JC. KazrinA is required for anxial elongation and epidermal integrity in Xenopus tropicalis. Dev Dyn. 2008 Jun: 237(6): 1718-1725.
  • Watt FM, Estrach S and Ambler CA. Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol. 2008 Apr;20(2):171-9. Review.
  • Palmer HG, Martinez D, Carmeliet G and Watt FM. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment. J Invest Dermatol. 2008 Aug;128(8):2113-7.
  • Celso CL, Berta MA, Braun KM, Frye M, Lyle S, Zouboulisr CC and Watt FM. Abstract
    Characterisation of Bipotential Epidermal Progenitors Derived from Human Sebaceous Gland: Contrasting Roles of c-Myc and {beta}-catenin. Stem Cells. 2008 May;26(5):1241-52.
  • Estrach S, Cordes R, Hozumi K, Gossler A, Watt FM. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis. J Invest Dermatol. 2008 Apr;128(4):825-32.
  • Watt FM, Frye M and Benitah SA. MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer. 2008 Mar;8(3):234-42. Erratum in: Nat Rev Cancer. 2008 Apr;8(4):316.
  • Torres J and Watt FM. Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkB and cooperating with Stat3. Nature Cell Biology. 2008. Vol 10(2). pp 194-201.
  • Giangreco A, Qin M, Pintar JE and Watt FM. Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell. 2008 Mar;7(2):250-9.
  • Palmer HG, Anjos-Afonso F, Carmeliet G, Takeda H and Watt FM. The Vitamin D receptor Is a Wnt Effector that controls Hair Follicle Differentiation and Specific Tumor Type in Adult Epidermis. PloS ONE. 2008 Jan 23:3(1):e1483
  • Watt FM and Server R. Cell Biology as the centuries change. J Cell Sci. 2008 Jan 1:121(Pt 1):1-2.

    2007

  • Jones PH, Simons BD and Watt FM. Sic transit gloria: farewell to the epidermal transit amplifying cell? Cell Stem Cell. 2007 Oct 11;1(4):371-81. Review.
  • Sevilla LM, Nachat R et al. Mice deficient in involucrin, envoplakin and periplakin have a defective epidermal barrier. The Journal of Cell Biology. 2007, 179(7), pp1599-1612.
  • Watt FM. Servering ties. J Cell Sci. Dec 15;120(Pt 24):4241.
  • Frye M, Fischer AG and Watt FM. Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. PLoS ONE. 2007 Aug 22;2(1):e763.
  • Estrach S, Legg J and Watt FM. Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci. 2007 Aug 15;120(Pt 16):2944-52. .
  • Ambler CA, Watt FM. Expression of Notch pathway genes in mammalian epidermis and modulation by beta-Catenin. Dev Dyn. 2007 Jun;236(6):1595-601.
  • Niemann C, Owens DM, Schettina P, Watt FM. Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type. Cancer Res. 2007 Apr 1;67(7):2916-21.
  • Benitah SA, Watt FM. Epidermal deletion of Rac1 causes stem cell depletion, irrespective of whether deletion occurs during embryogenesis or adulthood. J Invest Dermatol. 2007 Jun;127(6):1555-7.